Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology
Identifieur interne : 002817 ( Main/Exploration ); précédent : 002816; suivant : 002818Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology
Auteurs : Michael J. Bertoldo [France, Australie] ; Edith Guibert [France] ; Melanie Faure [France] ; Christelle Ramé [France] ; Marc Foretz [France] ; Benoit Viollet [France] ; Joëlle Dupont [France] ; Pascal Froment [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Animaux, Cadhérines (métabolisme), Cellules de la granulosa (métabolisme), Cellules de la granulosa (physiologie), Communication cellulaire (physiologie), Connexines (métabolisme), Femelle, Follicule ovarique (métabolisme), Jonctions communicantes (métabolisme), Mitochondries (métabolisme), Mitochondries (physiologie), Mâle, Métabolisme énergétique (physiologie), Ovocytes (métabolisme), Ovocytes (physiologie), Ovogenèse (physiologie), Phosphorylation (physiologie), Souris, Souris de lignée C57BL, Souris transgéniques, Transduction du signal (physiologie).
- MESH :
- métabolisme : AMP-Activated Protein Kinases, Cadhérines, Cellules de la granulosa, Connexines, Follicule ovarique, Jonctions communicantes, Mitochondries, Ovocytes.
- physiologie : Cellules de la granulosa, Communication cellulaire, Mitochondries, Métabolisme énergétique, Ovocytes, Ovogenèse, Phosphorylation, Transduction du signal.
- Animaux, Femelle, Mâle, Souris, Souris de lignée C57BL, Souris transgéniques.
English descriptors
- KwdEn :
- AMP-Activated Protein Kinases (metabolism), Animals, Cadherins (metabolism), Cell Communication (physiology), Connexins (metabolism), Energy Metabolism (physiology), Female, Gap Junctions (metabolism), Granulosa Cells (metabolism), Granulosa Cells (physiology), Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria (metabolism), Mitochondria (physiology), Oocytes (metabolism), Oocytes (physiology), Oogenesis (physiology), Ovarian Follicle (metabolism), Phosphorylation (physiology), Signal Transduction (physiology).
- MESH :
- chemical , metabolism : AMP-Activated Protein Kinases, Cadherins, Connexins.
- metabolism : Gap Junctions, Granulosa Cells, Mitochondria, Oocytes, Ovarian Follicle.
- physiology : Cell Communication, Energy Metabolism, Granulosa Cells, Mitochondria, Oocytes, Oogenesis, Phosphorylation, Signal Transduction.
- Animals, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic.
Abstract
Oogenesis and folliculogenesis are dynamic processes that are regulated by endocrine, paracrine and autocrine signals. These signals are exchanged between the oocyte and the somatic cells of the follicle. Here we analyzed the role of AMP-activated protein kinase (AMPK), an important regulator of cellular energy homeostasis, by using transgenic mice deficient in α1AMPK specifically in the oocyte. We found a decrease of 27% in litter size was observed in ZP3-α1AMPK-/- (ZP3-KO) female mice. Following
Url:
DOI: 10.1371/journal.pone.0119680
PubMed: 25767884
PubMed Central: 4359026
Affiliations:
- Australie, France
- Centre-Val de Loire, Région Centre, Île-de-France
- Nouzilly, Paris
- Université Paris-Descartes
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Le document en format XML
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Bertoldo</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Nouzilly</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>School of Women’s and Children’s Health, Discipline of Obstetrics and Gynaecology, University of New South Wales, Sydney, NSW, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Women’s and Children’s Health, Discipline of Obstetrics and Gynaecology, University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Guibert, Edith" sort="Guibert, Edith" uniqKey="Guibert E" first="Edith" last="Guibert">Edith Guibert</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><wicri:noRegion>37380, Nouzilly</wicri:noRegion><wicri:noRegion>37380, Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Faure, Melanie" sort="Faure, Melanie" uniqKey="Faure M" first="Melanie" last="Faure">Melanie Faure</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><wicri:noRegion>37380, Nouzilly</wicri:noRegion><wicri:noRegion>37380, Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Rame, Christelle" sort="Rame, Christelle" uniqKey="Rame C" first="Christelle" last="Ramé">Christelle Ramé</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><wicri:noRegion>37380, Nouzilly</wicri:noRegion><wicri:noRegion>37380, Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Foretz, Marc" sort="Foretz, Marc" uniqKey="Foretz M" first="Marc" last="Foretz">Marc Foretz</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM, U1016, Institut Cochin, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1016, Institut Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CNRS, UMR8104, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR8104, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Viollet, Benoit" sort="Viollet, Benoit" uniqKey="Viollet B" first="Benoit" last="Viollet">Benoit Viollet</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM, U1016, Institut Cochin, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1016, Institut Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CNRS, UMR8104, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR8104, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Dupont, Joelle" sort="Dupont, Joelle" uniqKey="Dupont J" first="Joëlle" last="Dupont">Joëlle Dupont</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><wicri:noRegion>37380, Nouzilly</wicri:noRegion><wicri:noRegion>37380, Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Froment, Pascal" sort="Froment, Pascal" uniqKey="Froment P" first="Pascal" last="Froment">Pascal Froment</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7247 INRA CNRS Université de Tours Haras Nationaux Physiologie de la Reproduction et des Comportements, 37380, Nouzilly</wicri:regionArea><wicri:noRegion>37380, Nouzilly</wicri:noRegion><wicri:noRegion>37380, Nouzilly</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term><term>Animals</term><term>Cadherins (metabolism)</term><term>Cell Communication (physiology)</term><term>Connexins (metabolism)</term><term>Energy Metabolism (physiology)</term><term>Female</term><term>Gap Junctions (metabolism)</term><term>Granulosa Cells (metabolism)</term><term>Granulosa Cells (physiology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Mitochondria (metabolism)</term><term>Mitochondria (physiology)</term><term>Oocytes (metabolism)</term><term>Oocytes (physiology)</term><term>Oogenesis (physiology)</term><term>Ovarian Follicle (metabolism)</term><term>Phosphorylation (physiology)</term><term>Signal Transduction (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term><term>Animaux</term><term>Cadhérines (métabolisme)</term><term>Cellules de la granulosa (métabolisme)</term><term>Cellules de la granulosa (physiologie)</term><term>Communication cellulaire (physiologie)</term><term>Connexines (métabolisme)</term><term>Femelle</term><term>Follicule ovarique (métabolisme)</term><term>Jonctions communicantes (métabolisme)</term><term>Mitochondries (métabolisme)</term><term>Mitochondries (physiologie)</term><term>Mâle</term><term>Métabolisme énergétique (physiologie)</term><term>Ovocytes (métabolisme)</term><term>Ovocytes (physiologie)</term><term>Ovogenèse (physiologie)</term><term>Phosphorylation (physiologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term><term>Transduction du signal (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term><term>Cadherins</term><term>Connexins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gap Junctions</term><term>Granulosa Cells</term><term>Mitochondria</term><term>Oocytes</term><term>Ovarian Follicle</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term><term>Cadhérines</term><term>Cellules de la granulosa</term><term>Connexines</term><term>Follicule ovarique</term><term>Jonctions communicantes</term><term>Mitochondries</term><term>Ovocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules de la granulosa</term><term>Communication cellulaire</term><term>Mitochondries</term><term>Métabolisme énergétique</term><term>Ovocytes</term><term>Ovogenèse</term><term>Phosphorylation</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Communication</term><term>Energy Metabolism</term><term>Granulosa Cells</term><term>Mitochondria</term><term>Oocytes</term><term>Oogenesis</term><term>Phosphorylation</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oogenesis and folliculogenesis are dynamic processes that are regulated by endocrine, paracrine and autocrine signals. These signals are exchanged between the oocyte and the somatic cells of the follicle. Here we analyzed the role of AMP-activated protein kinase (AMPK), an important regulator of cellular energy homeostasis, by using transgenic mice deficient in α1AMPK specifically in the oocyte. We found a decrease of 27% in litter size was observed in ZP3-α1AMPK<sup>-/- </sup>(ZP3-KO) female mice. Following <italic>in vitro</italic> fertilization, where conditions are stressful for the oocyte and embryo, ZP3-KO oocytes were 68% less likely to pass the 2-cell stage. <italic>In vivo</italic> and in cumulus-oocyte complexes, several proteins involved in junctional communication, such as connexin37 and N-cadherin were down-regulated in the absence of α1AMPK. While the two signalling pathways (PKA and MAPK) involved in the junctional communication between the cumulus/granulosa cells and the oocyte were stimulated in control oocytes, ZP3-KO oocytes exhibited only low phosphorylation of MAPK or CREB proteins. In addition, MII oocytes deficient in α1AMPK had a 3-fold lower ATP concentration, an increase in abnormal mitochondria, and a decrease in cytochrome C and PGC1α levels, suggesting perturbed energy production by mitochondria. The absence of α1AMPK also induced a reduction in histone deacetylase activity, which was associated with an increase in histone H3 acetylation (K9/K14 residues). Together, the results of the present study suggest that absence of AMPK, modifies oocyte quality through energy processes and oocyte/somatic cell communication. The limited effect observed <italic>in vivo</italic> could be partly due to a favourable follicle microenvironment where nutrients, growth factors, and adequate cell interaction were present. 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Centre</li><li>Île-de-France</li></region><settlement><li>Nouzilly</li><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Bertoldo, Michael J" sort="Bertoldo, Michael J" uniqKey="Bertoldo M" first="Michael J." last="Bertoldo">Michael J. Bertoldo</name></region><name sortKey="Dupont, Joelle" sort="Dupont, Joelle" uniqKey="Dupont J" first="Joëlle" last="Dupont">Joëlle Dupont</name><name sortKey="Faure, Melanie" sort="Faure, Melanie" uniqKey="Faure M" first="Melanie" last="Faure">Melanie Faure</name><name sortKey="Foretz, Marc" sort="Foretz, Marc" uniqKey="Foretz M" first="Marc" last="Foretz">Marc Foretz</name><name sortKey="Foretz, Marc" sort="Foretz, Marc" uniqKey="Foretz M" first="Marc" last="Foretz">Marc Foretz</name><name sortKey="Foretz, Marc" sort="Foretz, Marc" uniqKey="Foretz M" first="Marc" last="Foretz">Marc Foretz</name><name sortKey="Froment, Pascal" sort="Froment, Pascal" uniqKey="Froment P" first="Pascal" last="Froment">Pascal Froment</name><name sortKey="Guibert, Edith" sort="Guibert, Edith" uniqKey="Guibert E" first="Edith" last="Guibert">Edith Guibert</name><name sortKey="Rame, Christelle" sort="Rame, Christelle" uniqKey="Rame C" first="Christelle" last="Ramé">Christelle Ramé</name><name sortKey="Viollet, Benoit" sort="Viollet, Benoit" uniqKey="Viollet B" first="Benoit" last="Viollet">Benoit Viollet</name><name sortKey="Viollet, Benoit" sort="Viollet, Benoit" uniqKey="Viollet B" first="Benoit" last="Viollet">Benoit Viollet</name><name sortKey="Viollet, Benoit" sort="Viollet, Benoit" uniqKey="Viollet B" first="Benoit" last="Viollet">Benoit Viollet</name></country><country name="Australie"><noRegion><name sortKey="Bertoldo, Michael J" sort="Bertoldo, Michael J" uniqKey="Bertoldo M" first="Michael J." last="Bertoldo">Michael J. 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